Enhancing the Resin-Dentin Bond with DMSO: A Narrative Review

(Pages: 40-46)

Rajni Nagpal, Nida Mehmood and Udai Pratap Singh

Department of Conservative Dentistry and Endodontics, Kothiwal Dental College and Research Centre, Moradabad, -244001, U P, India

DOI: http://dx.doi.org/10.30576/2414-2050.2019.05.7



Abstract: The limited durability of resin-dentin bonds is mainly attributed to host-derived enzymatic degradation of the organic component of adhesive interface and hydrolytic degradation of the adhesive resin. Deterioration of resin dentin bond can lead to microleakage, secondary caries, loss of restoration and tooth structure over time. Methods to increase the durability of resin restorations mainly focus on strategies to improve the infiltration of adhesive monomers into demineralized dentin matrix, and inhibition of endogenous enzymatic activity that cause the degradation of the collagen part of the hybrid layer. Dimethyl sulfoxide (DMSO) is a polar aprotic solvent which is considered as one of the best penetration enhancers for medical purposes, because of its ability to penetrate biological surface and the ability to dissolve several dental monomers and components. Recent research has demonstrated that DMSO pretreatment could be used to improve the resin dentin bond durability. Therefore, this review discusses DMSO as a potential dentin biomodifying agent, including its chemical properties, effect on dentin wettability and resin infiltration, inhibitory effect on endogenous dentinal enzymes, its role as a potential solvent for dental adhesives, potential toxicity and addresses the current literature to critically assess its effect on improving the longevity of resin dentin bond.

Keywords: Adhesion, DMSO, bond, strength, MMPs.