Effects of Topical Use of Metronidazole in Causal Therapy in Patients Suffering from Chronic Periodontitis: A Case-Control Clinical Trial 

(Pages: 14-22)

G. Montaruli, S. Leone, M. Laurenziello, D. Ciavarella, L. Guida and L. Lo Russo

Department of Clinical and Experimental Medicine, School of Dentistry, University of Foggia, Via Rovelli 48, Foggia, Italy

DOI: http://dx.doi.org/10.30576/2414-2050.2019.05.3



Abstract: Purpose: The purpose of this study is to evaluate the effects of topical metronidazole in addition to non-surgical causal therapy in patients suffering from chronic periodontitis.

Materials and Methods: The study involved a sample of 17 patients with chronic periodontitis. The sample was divided into 2 groups treated in two different centers: test and control. The test group underwent the application of topical metronidazole after scaling and root planing, while the control group received exclusively SRP.

Results: The difference in pre- and post-therapy PPD values in both groups were calculated: both mechanical therapy and mechanical therapy with the addition of topical metronidazole had a significant effect on the variation of PPD values. The best results were obtained in test group. The evaluation of mean FMBS variation from the baseline in the two groups showed a greater reduction in the test group.

Conclusions: The present study showed that the use of topical metronidazole in addition to the non-surgical causal therapy in patients with chronic periodontitis resulted in a better response to treatment than mechanical therapy only.

Keywords: Chronic periodontitis, Metronidazole, Scaling-Root Planing, Non-surgical causal therapy.